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MYP_097380
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Basic Information
Saposin-like protein SPP-12
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
78 amino acids
C378H588N98O124S6
Standard
Sequence
GSHGAFCHLCEDLIKDGKEAGDVALDVWLDEEIGSRCKDFGVLASECFKELKVAEHDIWEAIDQEIPEDKTCKEAKLC
Physicochemical Analysis
8681.68 Da
4.46
-11.00
-11.48
-0.1411
-0.33
0.60
-0.01
31.78
83.85
0.0641
11000.00
11375.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
3552.92
-30.31
125.0
122.0
298.0
606.0
11.0
78.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0223750 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Jurkat cancer cells
PMID22519640 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22519640/
RECORD: Rec_0266149 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Bacillus thuringiensis B-18247
10 μM
MBC
PMID22519640 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22519640/
RECORD: Rec_0285188 VERIFIED: YES
Provenance & Taxonomy
Caenorhabditis elegans [Animal]
6239
Structure & Mods
side-chain cyclized/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
Tumor cells: Jurkat (Low active up to 10 μM )
PMID22519640 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22519640/
RECORD: Rec_0315177 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Dictyostelium discoideum Ax3-ORF[LC >1 microM
PMID22519640 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22519640/
RECORD: Rec_0356905 VERIFIED: YES
Provenance & Taxonomy
Caenorhabditis elegans [Animal]
6239
Structure & Mods
side-chain cyclized/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
PMID22519640 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22519640/
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