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MYP_097370
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Basic Information
Centrocin 2
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Standard
30 amino acids
C135H215N45O38S
Standard
Sequence
SWFSRTVHNVGNAVRKGIHAGQGVCSGLGL
Physicochemical Analysis
3108.49 Da
10.86
2.62
2.30
0.0875
0.05
0.74
0.13
16.77
84.33
0.0667
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1340.38
-17.09
49.0
44.0
101.0
219.0
5.0
32.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0257487 VERIFIED: YES
Provenance & Taxonomy
Strongylocentrotus droebachiensis [other]
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
The single Cys residue will link with another short peptide chain DLRAICAGAHAL to form the complete two chain AMP. In addition, the Trp residue is brominated
Bio-Activity Profile
Antimicrobial
Staphylococcus aureus ATCC 9144
5.0 μM
MIC
PaperCentrocins: Isolation and characterization of novel dimeric antimicrobial peptides from the green sea urchin, Strongylocentrotus droebachiensis
RECORD: Rec_0257793 VERIFIED: YES
Provenance & Taxonomy
Strongylocentrotus droebachiensis [Animal]
Centrocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
PaperDev Comp Immunol. 2010 Sep;34(9):959-68. | http://www.ncbi.nlm.nih.gov/pubmed/20438753 PMID20438753 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20438753/
RECORD: Rec_0272955 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
W at position 2 is brominated
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0410380 VERIFIED: YES
Provenance & Taxonomy
Strongylocentrotus droebachiensis [other]
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
The single Cys residue will link with another short peptide chain DLRAICAGAHAL to form the complete two chain AMP. In addition, the Trp residue is brominated
Bio-Activity Profile
Antimicrobial
Escherichia coli ATCC 25922
2.5 μM
MIC
PaperCentrocins: Isolation and characterization of novel dimeric antimicrobial peptides from the green sea urchin, Strongylocentrotus droebachiensis
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