Peptide Database

Peptide NameAbatacept

Function Ontology

Immunology ▸ Immune modulation ▸ Immunomodulatory activity

Immunology ▸ Immunomodulation ▸ Immunosuppressive

Standard StatusStandard

Sequence Length255 amino acids

Chemical FormulaC1235H1948N326O386S13

DescriptionStandard

        MHVAQPAVVLASSRGIASFVCEYASPGKATEVRVTVLRQADSQVTEVCAATYMMGNELTFLDDSICTGTSSGNQVNLTIQGLRAMDTGLYICKVELMYPPPYYLGIGNGTQIYVIDPEPCPDSDQEPKSSDKTHTSPPSPAPELLGGSSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPRE
    

Molecular Weight27955.48 Da

Isoelectric Point (pI)5.46

Net Charge (pH 7.0)-6.09

Net Charge (pH 7.4) -6.74

Charge Density (pH 7.0) -0.0239

GRAVY Index-0.32

Hydrophobic Moment 0.55

Boman Index0.02

Instability Index44.10

Aliphatic Index 77.88

Aromaticity 0.0706

Extinction Coeff. Reduced 27390.00

Extinction Coeff. Oxidized 27765.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0399555 VERIFIED: YES

Provenance & Taxonomy

OrganismCricetulus griseus [Animal]

FamilyFusion protein

Tax ID10029

Structure & Mods

Configlinear multidomain protein biologic [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Immunomodulatory Immunosuppressive T-cell costimulation blocker

Half-Life16.7 (12-23) d in healthy subjects

PaperPubMed-linked source references: PMID:20080922; PMID:19821401; PMID:18041889; PMID:17212998; PMID:17014006; PMID:16971318; PMID:16932686; PMID:16573350; PMID:16557658 PMID20080922;19821401;18041889;17212998;17014006;16971318;16932686;16573350;16557658 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20080922/ PatentCA2110518