Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length487 amino acids

Chemical FormulaC2421H3864N640O682S18

DescriptionStandard

        KGGMTRGPDSMPQWAILVVLTTMGTAVTAATNPGLLTRISQKGLDYACQKGVAMLQKELEKIKIPDFSGNFKIQHLGKGYYSFYSMTILGFQLPSPQIRLEPQVGLRLSISKANVKISGKWKGKKNFFSASGKFDLSIEGVSISAFLNLGSDPTSGHITVACSSCGSHISNTRLRIWGSTVGWLIQLFHKKIESSLRNTLNSKICKFVANSVSTQLQAYVKNFPVTTQIDAVAGIDYRLVAPPITTAENLDGQLKGEFFSQAHRSPPPFTPPAMAFPEDHDRMVYLGISDYFFNTAGLVYQEAGALKLTLQDHMMPNGSKFLLTTKSLGNVLPQVAKMFPNMKVQLQVSVSTPPQLNTQPTGLTLTPKLEVQAFVILPNSSLVPLFLLSMTASAALEVGARSNRLVGELQVDSRLILKLKRSNIGPFQVELLQTVMDYVVHTVLLPRVNEKLKTAFPLPMPARVQLYNLLLQSHQNFLQFGADVNLV
    

Molecular Weight53425.63 Da

Isoelectric Point (pI)9.68

Net Charge (pH 7.0)18.52

Net Charge (pH 7.4) 17.71

Charge Density (pH 7.0) 0.0380

GRAVY Index0.04

Hydrophobic Moment 0.65

Boman Index0.12

Instability Index38.76

Aliphatic Index 97.27

Aromaticity 0.0821

Extinction Coeff. Reduced 38390.00

Extinction Coeff. Oxidized 38640.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0344023 VERIFIED: NO

Provenance & Taxonomy

OrganismMarmota marmota marmota [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria

MethodQualitative functional evidence