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MYP_097089
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Basic Information
N-3 (analog of P18)
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
16 amino acids
C106H163N25O17
Standard
Sequence
KWFKKIPKFLHLAKKF
Physicochemical Analysis
2059.59 Da
10.70
5.84
5.58
0.3651
-0.42
0.81
-0.05
-7.12
79.38
0.2500
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
691.62
1.53
24.0
24.0
70.0
148.0
7.0
15.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0181270 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer Antibacterial Toxic Antimicrobial Hemolytic
PaperAntibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs; CancerPPD: a database of anticancer peptides and proteins PMID12005420;25270878 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25270878/
RECORD: Rec_0288047 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antibacterial Antimicrobial Anti-Gram-positive Anti-Gram-negative Anticancer
Escherichia coli KCTC 1682
12.5 μM
MIC
PaperAntibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs. J Pept Res. 2001 Dec;58(6):504-14. doi: 10.1034/j.1399-3011.2001.00934.x. PMID: 12005420. PMID12005420 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12005420/
RECORD: Rec_0293510 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Cytotoxic Anticancer Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Tumor cells: MDA-MB-361
17 μM
IC50
PaperAntibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs. J Pept Res. 2001 Dec;58(6):504-14. doi: 10.1034/j.1399-3011.2001.00934.x. PMID: 12005420. PMID12005420 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12005420/
RECORD: Rec_0374828 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cecropin
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Cytotoxic Anticancer
MDA-MB-361
17 μM
IC50
PaperAntibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs PMID12005420 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12005420/
RECORD: Rec_0383874 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
50557
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Anticancer
PMID12005420 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12005420/
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