Peptide Database

Peptide NameSLAY-screened peptide P4460

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC106H170N32O31

DescriptionStandard

        PLVRYDQRTSPLHHETIVNI
    

Molecular Weight2388.68 Da

Isoelectric Point (pI)7.33

Net Charge (pH 7.0)0.14

Net Charge (pH 7.4) -0.03

Charge Density (pH 7.0) 0.0068

GRAVY Index-0.56

Hydrophobic Moment 0.46

Boman Index-0.09

Instability Index57.27

Aliphatic Index 107.00

Aromaticity 0.0500

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1016.30

LogP -9.32

H-bond Donors 36.0

H-bond Acceptors 33.0

Rotatable Bonds 75.0

Heavy Atoms 169.0

Ring Count 5.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0232921 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/