Peptide Database

Peptide NameHD5[E21R]

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antiviral

Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV

Antiviral ▸ Anti-HIV ▸ Anti-HIV-1

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length32 amino acids

Chemical FormulaC145H249N53O43S6

DescriptionStandard

        ATCYCRTGRCATRESLSGVCRISGRLYRLCCR
    

Molecular Weight3615.25 Da

Isoelectric Point (pI)9.49

Net Charge (pH 7.0)5.74

Net Charge (pH 7.4) 5.46

Charge Density (pH 7.0) 0.1793

GRAVY Index-0.14

Hydrophobic Moment 0.79

Boman Index-0.27

Instability Index7.77

Aliphatic Index 64.06

Aromaticity 0.0625

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 3355.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1597.86

LogP -21.50

H-bond Donors 69.0

H-bond Acceptors 55.0

Rotatable Bonds 119.0

Heavy Atoms 247.0

Ring Count 2.0

Amide Bonds 31.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0354128 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configcyclic/stapled peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Disulfide3-31, 5-20, 10-30

Bio-Activity Profile

Function

Antimicrobial Antiviral

TargetCaSki cells up to 100μg/ ml

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