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MYP_097050
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Basic Information
HD5[E21R]
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
32 amino acids
C145H249N53O43S6
Standard
Sequence
ATCYCRTGRCATRESLSGVCRISGRLYRLCCR
Physicochemical Analysis
3615.25 Da
9.49
5.74
5.46
0.1793
-0.14
0.79
-0.27
7.77
64.06
0.0625
2980.00
3355.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1597.86
-21.50
69.0
55.0
119.0
247.0
2.0
31.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0197806 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Defensin
9606;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Sequence-variant derivative
Bio-Activity Profile
Antiviral Entry inhibitor
Herpes simplex virus 2 (Virus entry); CaSki
6.915129 μM
Plaque assay
PaperEnhancement of antiviral activity of human alpha-defensin 5 against herpes simplex virus 2 by arginine mutagenesis at adaptive evolution sites. | Wang A, Chen F, Wang Y, Shen M, Xu Y, Hu J, Wang S, Geng F, Wang C, Ran X, Su Y, Cheng T, Wang J. | J Virol. 2013 | PMID:23269800 PMID23269800 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23269800/
RECORD: Rec_0204772 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
3-31, 5-20, 10-30
Bio-Activity Profile
Antimicrobial Antiviral
Herpes simplex virus2(HSV-2):Potential for CaSki cell protection from HSV-2 infection(61.5% ± 7.1% cell protection rates at 25 μg/ml,90.2% ± 4.9% cell protection at 50 μg/ml)
PaperPubMed PMID: 23269800 PMID23269800 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23269800/
RECORD: Rec_0259015 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Defensin
32630
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
3-31, 5-20, 10-30
Disulfide bonds between Cys3 and Cys31,Cys5 and Cys20,Cys10 and Cys30.
Bio-Activity Profile
Antiviral Anti-HIV-1 Entry inhibition
HIV-1 | JLTRG cells
3.53 μg/mL
IC50
Mammalian: 4.4 h; Yeast: >20 h; E. coli: >10 h
PaperEnhancement of antiviral activity of human alpha-defensin 5 against herpes simplex virus 2 by arginine mutagenesis at adaptive evolution sites. | Wang A, Chen F, Wang Y, Shen M, Xu Y, Hu J, Wang S, Geng F, Wang C, Ran X, Su Y, Cheng T, Wang J. | J Virol. 2013 Mar;87(5):2835-45. | DOI:10.1128/JVI.02209-12 | PMID:23269800 PMID23269800 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23269800/
RECORD: Rec_0276114 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
3-31, 5-20, 10-30
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
PaperPubMed PMID: 23269800 PMID23269800 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23269800/
RECORD: Rec_0323205 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/
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