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MYP_097050
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Basic Information
HD5[E21R]
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
32 amino acids
C145H249N53O43S6
Standard
Sequence
ATCYCRTGRCATRESLSGVCRISGRLYRLCCR
Physicochemical Analysis
3615.25 Da
9.49
5.74
5.46
0.1793
-0.14
0.79
-0.27
7.77
64.06
0.0625
2980.00
3355.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1597.86
-21.50
69.0
55.0
119.0
247.0
2.0
31.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0066730 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
3-31, 5-20, 10-30
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1:inhibition of virus infection in JLTRG cells
3.53 μg/
IC50
PaperPubMed PMID: 23269800 PMID23269800 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23269800/
RECORD: Rec_0071148 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
3-31, 5-20, 10-30
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 23269800 PMID23269800 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23269800/
RECORD: Rec_0158979 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
3-31, 5-20, 10-30
Bio-Activity Profile
Antimicrobial Antiviral
neutralization activity against HSV-2 during the preinfection stage
25 μg/mL
IC50
PaperPubMed PMID: 23269800 PMID23269800 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23269800/
RECORD: Rec_0184128 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Defensin
32630
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
3-31, 5-20, 10-30
Disulfide bonds between Cys3 and Cys31,Cys5 and Cys20,Cys10 and Cys30.
Bio-Activity Profile
Antiviral Anti-HSV Entry inhibition
Herpes simplex virus2 (HSV-2) | CaSki cell
25 μg/mL
% inhibition
Mammalian: 4.4 h; Yeast: >20 h; E. coli: >10 h
PaperEnhancement of antiviral activity of human alpha-defensin 5 against herpes simplex virus 2 by arginine mutagenesis at adaptive evolution sites. | Wang A, Chen F, Wang Y, Shen M, Xu Y, Hu J, Wang S, Geng F, Wang C, Ran X, Su Y, Cheng T, Wang J. | J Virol. 2013 Mar;87(5):2835-45. | DOI:10.1128/JVI.02209-12 | PMID:23269800 PMID23269800 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23269800/
RECORD: Rec_0189641 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Defensin
32630
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
3-31, 5-20, 10-30
Disulfide bonds between Cys3 and Cys31,Cys5 and Cys20,Cys10 and Cys30.
Bio-Activity Profile
Antiviral Anti-HSV Entry inhibition
neutralization activity against HSV-2 during the preinfection stage
6.915 μM
IC50
Mammalian: 4.4 h; Yeast: >20 h; E. coli: >10 h
PaperEnhancement of antiviral activity of human alpha-defensin 5 against herpes simplex virus 2 by arginine mutagenesis at adaptive evolution sites. | Wang A, Chen F, Wang Y, Shen M, Xu Y, Hu J, Wang S, Geng F, Wang C, Ran X, Su Y, Cheng T, Wang J. | J Virol. 2013 Mar;87(5):2835-45. | DOI:10.1128/JVI.02209-12 | PMID:23269800 PMID23269800 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23269800/
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