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MYP_097039
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Basic Information
Linear Cyclotide Panitide L1
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
not Standard
28 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
XLPICGETCVLGTCYTPGCRCQYPICVR
Physicochemical Analysis
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0049874 VERIFIED: YES
Provenance & Taxonomy
Steinchisma laxum [Plant]
Cyclotide
Structure & Mods
linear cystine-knot peptide [Linear]
noncanonical residue-modified peptide [Modified]
Pyroglutamate
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Pyroglutamate at position 1
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive
Staphylococcus aureus
PaperDiscovery of linear cyclotides in monocot plant Panicum laxum of Poaceae family provides new insights into evolution and distribution of cyclotides in plants PMID23195955 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23195955/
RECORD: Rec_0069256 VERIFIED: NO
Provenance & Taxonomy
Steinchisma laxum [Plant]
Cyclotide
Structure & Mods
linear cystine-knot peptide [Linear]
noncanonical residue-modified peptide [Modified]
Pyroglutamate
5-19, 9-21, 14-26.
Pyroglutamate at position 1
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0177807 VERIFIED: YES
Provenance & Taxonomy
Steinchisma laxum [Plant]
Cyclotide
Structure & Mods
linear cystine-knot peptide [Linear]
noncanonical residue-modified peptide [Modified]
Pyroglutamate
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Pyroglutamate at position 1
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-negative
Escherichia coli
PaperDiscovery of linear cyclotides in monocot plant Panicum laxum of Poaceae family provides new insights into evolution and distribution of cyclotides in plants PMID23195955 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23195955/
RECORD: Rec_0194597 VERIFIED: YES
Provenance & Taxonomy
Steinchisma laxum [Plant]
Cyclotide
Structure & Mods
linear cystine-knot peptide [Linear]
noncanonical residue-modified peptide [Modified]
Pyroglutamate
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Pyroglutamate at position 1
Bio-Activity Profile
Antifungal Antimicrobial Antibacterial
Candida albicans
PaperDiscovery of linear cyclotides in monocot plant Panicum laxum of Poaceae family provides new insights into evolution and distribution of cyclotides in plants PMID23195955 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23195955/
RECORD: Rec_0203296 VERIFIED: YES
Provenance & Taxonomy
Steinchisma laxum [Plant]
Cyclotide
Structure & Mods
linear cystine-knot peptide [Linear]
noncanonical residue-modified peptide [Modified]
Pyroglutamate
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Pyroglutamate at position 1
Bio-Activity Profile
Antifungal Antimicrobial Antibacterial
Candida tropicalis
PaperDiscovery of linear cyclotides in monocot plant Panicum laxum of Poaceae family provides new insights into evolution and distribution of cyclotides in plants PMID23195955 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23195955/
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