Peptide Database

Peptide NameBeta-defensin 133

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length61 amino acids

Chemical FormulaC332H508N84O78S9

DescriptionStandard

        MKIHVFLFVLFFFLVPIATRVKCAVKDTYSCFIMRGKCRHECHDFEKPIGFCTKLNANCYM
    

Molecular Weight7212.69 Da

Isoelectric Point (pI)9.06

Net Charge (pH 7.0)4.70

Net Charge (pH 7.4) 4.23

Charge Density (pH 7.0) 0.0771

GRAVY Index0.42

Hydrophobic Moment 0.52

Boman Index0.15

Instability Index35.46

Aliphatic Index 79.84

Aromaticity 0.1639

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 3355.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2576.36

LogP -13.83

H-bond Donors 96.0

H-bond Acceptors 95.0

Rotatable Bonds 235.0

Heavy Atoms 503.0

Ring Count 15.0

Amide Bonds 62.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0080832 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyDefensin

Tax ID9606

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Defensin Non-hemolytic Non-ribosomal

MethodQualitative functional evidence

PaperCross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract PMID16033865 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16033865/; https://www.uniprot.org/uniprotkb/Q30KQ1/entry; https://bblserver.org.in/ampdb/