Peptide Database

Peptide NameCocaine- and amphetamine-regulated transcript protein

Function Ontology

Cardiovascular

Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory

Hormonal / Endocrine ▸ Hormone peptide

Metabolic ▸ Appetite and feeding regulation ▸ Feeding regulator

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Regulatory peptide ▸ Biological modulation

Regulatory peptide ▸ Biological regulation

Standard StatusStandard

Sequence Length66 amino acids

Chemical FormulaC325H546N94O93S6

DescriptionStandard

        HEKELIEALQEVLKKLKSKRIPIYEKKYGQVPMCDAGEQCAVRKGARIGKLCDCPRGTSCNSFLLK
    

Molecular Weight7450.78 Da

Isoelectric Point (pI)9.25

Net Charge (pH 7.0)5.80

Net Charge (pH 7.4) 5.45

Charge Density (pH 7.0) 0.0880

GRAVY Index-0.50

Hydrophobic Moment 0.76

Boman Index-0.16

Instability Index27.39

Aliphatic Index 84.24

Aromaticity 0.0455

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 3230.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3057.07

LogP -27.84

H-bond Donors 110.0

H-bond Acceptors 106.0

Rotatable Bonds 262.0

Heavy Atoms 518.0

Ring Count 7.0

Amide Bonds 69.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0074271 VERIFIED: NO

Provenance & Taxonomy

OrganismSus scrofa [Animal]

FamilyCocaine- and amphetamine-regulated transcript protein

Tax ID9823

Structure & Mods

Configdisulfide-constrained peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide34-52; 40-60

Bio-Activity Profile

Function

Hormone Endocrine Neuropeptide Neuromodulator Cardiovascular Metabolic regulation Physiological regulation Growth regulation Development regulation Receptor modulation ACE inhibitory Feeding regulator

Half-LifeMammalian: 3.5 hour; Yeast: 10 min; E. coli: >10 hour

RECORD: Rec_0193257 VERIFIED: NO