Peptide Database

Peptide NameBeta-defensin 134

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length59 amino acids

Chemical FormulaC316H487N73O79S10

DescriptionStandard

        MKPLLVVFVFLFLWDPVLAEMHKKCYKNGICRLECYESEMLVAYCMFQLECCVKGNPAP
    

Molecular Weight6893.34 Da

Isoelectric Point (pI)6.52

Net Charge (pH 7.0)-0.46

Net Charge (pH 7.4) -0.84

Charge Density (pH 7.0) -0.0079

GRAVY Index0.47

Hydrophobic Moment 0.53

Boman Index0.21

Instability Index52.63

Aliphatic Index 94.07

Aromaticity 0.1356

Extinction Coeff. Reduced 9970.00

Extinction Coeff. Oxidized 10345.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2386.42

LogP -8.97

H-bond Donors 85.0

H-bond Acceptors 90.0

Rotatable Bonds 222.0

Heavy Atoms 478.0

Ring Count 14.0

Amide Bonds 61.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0375755 VERIFIED: NO

Provenance & Taxonomy

OrganismPan troglodytes [Animal]

FamilyDefensin

Tax ID9598

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Defensin Non-hemolytic Non-ribosomal

MethodQualitative functional evidence

PaperCross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract PMID16033865 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16033865/; https://www.uniprot.org/uniprotkb/Q30KJ5/entry; https://bblserver.org.in/ampdb/