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MYP_096750
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Basic Information
Mastoparan-L
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide
Delivery / Targeting ▸ Drug delivery vehicle
Hormonal / Endocrine ▸ Hormone peptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Venom / Toxin ▸ General toxin ▸ Toxin
Venom / Toxin ▸ Toxin
Standard
14 amino acids
C70H130N18O16
Standard
Sequence
INLKALAALAKKIL
Physicochemical Analysis
1479.89 Da
10.30
2.76
2.55
0.1969
1.16
0.58
0.30
10.91
195.71
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
562.77
-1.68
19.0
19.0
53.0
104.0
0.0
14.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0236214 VERIFIED: YES
Provenance & Taxonomy
Vespula flaviceps [Animal]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Cell degranulating
PMID540362 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/540362/
RECORD: Rec_0244860 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0259908 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Toxic
PaperHirai Y., Yasuhara T., Yoshida H., Nakajima T., Fujino M., Kitada C.. A new mast cell degranulating peptide "mastoparan" in the venom of Vespula lewisii. Chem. Pharm. Bull., 27, 1942-1944, 1979.
RECORD: Rec_0262638 VERIFIED: YES
Provenance & Taxonomy
Vespula lewisii [Animal]
Mastoparan
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa PAO1
8 μM
MIC
PMID31411881 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31411881/
RECORD: Rec_0276307 VERIFIED: YES
Provenance & Taxonomy
Vespula lewisii [Animal]
MCD family
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Toxin Venom MCD family
PaperPDB 1D7N structural record; NMR; chain A; residues 1-14
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