Peptide Database

Peptide NameSLAY-screened peptide P998

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length11 amino acids

Chemical FormulaC48H79N17O18

DescriptionStandard

        RPPVNSHTSST
    

Molecular Weight1182.24 Da

Isoelectric Point (pI)9.76

Net Charge (pH 7.0)0.85

Net Charge (pH 7.4) 0.59

Charge Density (pH 7.0) 0.0770

GRAVY Index-1.27

Hydrophobic Moment 0.24

Boman Index-0.28

Instability Index72.27

Aliphatic Index 26.36

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 571.56

LogP -10.24

H-bond Donors 20.0

H-bond Acceptors 20.0

Rotatable Bonds 33.0

Heavy Atoms 83.0

Ring Count 3.0

Amide Bonds 11.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0055641 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/