Peptide Database

Peptide NamePituitary adenylate cyclase-activating polypeptide

Function Ontology

Hormonal / Endocrine ▸ Hormone peptide

Metabolic

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Standard StatusStandard

Sequence Length38 amino acids

Chemical FormulaC202H326N68O55S

DescriptionStandard

        HSDGIFTDSYSRYRKQMAVQKYLAAVLGRRYRQRVRNK
    

Molecular Weight4619.24 Da

Isoelectric Point (pI)11.00

Net Charge (pH 7.0)7.84

Net Charge (pH 7.4) 7.58

Charge Density (pH 7.0) 0.2064

GRAVY Index-1.10

Hydrophobic Moment 0.67

Boman Index-0.42

Instability Index43.86

Aliphatic Index 61.58

Aromaticity 0.1316

Extinction Coeff. Reduced 5960.00

Extinction Coeff. Oxidized 5960.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2088.86

LogP -22.27

H-bond Donors 78.0

H-bond Acceptors 65.0

Rotatable Bonds 158.0

Heavy Atoms 326.0

Ring Count 6.0

Amide Bonds 41.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0063297 VERIFIED: YES

Provenance & Taxonomy

OrganismUranoscopus japonicus [Animal]

FamilyGlucagon

Tax ID70848

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Hormone Metabolic

RECORD: Rec_0072959 VERIFIED: NO

Provenance & Taxonomy

OrganismUranoscopus japonicus [Animal],Pleuronectes ferrugineus,Limanda ferruginea [Animal]; Hippoglossus hippoglossus [Animal]; Oryzias latipes [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Enzyme Activator

RECORD: Rec_0111376 VERIFIED: YES

Provenance & Taxonomy

OrganismUranoscopus japonicus [Animal]

FamilyPituitary adenylate cyclase-activating polypeptide

Tax ID70848

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Hormone Endocrine Neuropeptide Neuromodulator

Targetpituitary cells

Half-LifeMammalian: 3.5 hour; Yeast: 10 min; E. coli: >10 hour

RECORD: Rec_0218349 VERIFIED: YES

Provenance & Taxonomy

OrganismUranoscopus japonicus [Animal]

FamilyPituitary adenylate cyclase-activating polypeptide

Tax ID70848

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Hormone Endocrine Neuropeptide Neuromodulator

Half-LifeMammalian: 3.5 hour; Yeast: 10 min; E. coli: >10 hour