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MYP_096639
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Basic Information
SB105-A10
Antimicrobial
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition ▸ Replication inhibitor
Standard
9 amino acids
C47H91N17O11
Standard
Sequence
ASLRVRIKK
Physicochemical Analysis
1070.33 Da
12.00
3.79
3.60
0.4215
-0.37
0.21
-0.46
20.86
130.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
492.19
-4.18
19.0
15.0
39.0
75.0
0.0
8.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0046133 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Replication inhibitor
Herpes simplex virus 2 (Replication); Vero
0.77 μM
EC50
PaperReduced HIV transmission at subsequent pregnancy in a resource-poor setting. | Gumbo FZ, Kandawasvika GQ, Duri K, Mapingure MP, Kurewa NE, Nathoo K, Rusakaniko S, Chirenje MZ, Stray-Pedersen B. | Trop Doct. 2011 | PMID:21576348 PMID21576348 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21576348/
RECORD: Rec_0086200 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Entry inhibitor
Human cytomegalovirus (Virus entry); UL54 2F7
90 %
EGFP expression
PaperPeptide-derivatized dendrimers inhibit human cytomegalovirus infection by blocking virus binding to cell surface heparan sulfate. | Luganini A, Giuliani A, Pirri G, Pizzuto L, Landolfo S, Gribaudo G. | Antiviral Res. 2010 | PMID:20083141 PMID20083141 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20083141/
RECORD: Rec_0101927 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 0.0%, T 44.4%, C 55.6% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/
RECORD: Rec_0147256 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Entry inhibitor
Respiratory syncytial virus (Virus entry); A549
0.25 μM
Plaque assay
PaperInhibition of human respiratory syncytial virus infectivity by a dendrimeric heparan sulfate-binding peptide. | Donalisio M, Rusnati M, Cagno V, Civra A, Bugatti A, Giuliani A, Pirri G, Volante M, Papotti M, Landolfo S, Lembo D. | Antimicrob Agents Chemother. 2012 | PMID:22850525 PMID22850525 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22850525/
RECORD: Rec_0222960 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Replication inhibitor
Herpes simplex virus 1 (Replication); Vero
0.25 μM
EC50
PaperReduced HIV transmission at subsequent pregnancy in a resource-poor setting. | Gumbo FZ, Kandawasvika GQ, Duri K, Mapingure MP, Kurewa NE, Nathoo K, Rusakaniko S, Chirenje MZ, Stray-Pedersen B. | Trop Doct. 2011 | PMID:21576348 PMID21576348 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21576348/