Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length487 amino acids

Chemical FormulaC2433H3850N644O686S21

DescriptionStandard

        TREDMARGPCNAPRWASLLVLVVVGTAVAAAINPGVMVRISQKGLDYATQQGTAALQKELERIKIPDYSGSFKIKHLGKGHYSFYSMDIREFQLPSSQIRMVPNVGLKFSISNANIKISGKWRAHKSFLKTSGRFDLSIEGMSISADLKLGSNLTSGKPTVTCSSCSSHISSVHVHISDSKVGWLIQLFHKKIESALRNKLNSQVCQEVTSSVSSKLQPYFQTLPVMTKIDAVAGINYGLVAPPTTTAETLDVQMKGEFYRLNHHNPPPFAPPVMEFPAAHDRMVYLGLSDYFFNTAGLVYQEAGVLKMTLTDDMIPKESKFRLTTQFFGSFLPEVAKMFPNMKIQIHISASAPPQVSVQPTGLSFFPDLDVQAFAVLANSSLASLFLIGMSTHGSLEVGARSDRLVGELKVDRLLLELKHSNIGPFPVELLQDIMNYLVPILVLPRVNEKLQKGFPLPMPARVQLYNMVLQSHQNFLLFGADVVYK
    

Molecular Weight53771.86 Da

Isoelectric Point (pI)9.31

Net Charge (pH 7.0)11.61

Net Charge (pH 7.4) 10.54

Charge Density (pH 7.0) 0.0238

GRAVY Index0.02

Hydrophobic Moment 0.70

Boman Index0.11

Instability Index40.68

Aliphatic Index 94.66

Aromaticity 0.0862

Extinction Coeff. Reduced 35870.00

Extinction Coeff. Oxidized 36120.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0221102 VERIFIED: NO

Provenance & Taxonomy

OrganismSaimiri boliviensis boliviensis [Animal]

FamilyBPI/LBP

Tax ID39432

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria