Peptide Database

Peptide NameStRIP3[L911F,S912Y]

Function Ontology

Anticancer

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length17 amino acids

Chemical FormulaC98H127N21O32

DescriptionStandard

        DDESEQFSYHLFYFNAV
    

Molecular Weight2111.18 Da

Isoelectric Point (pI)4.05

Net Charge (pH 7.0)-4.15

Net Charge (pH 7.4) -4.41

Charge Density (pH 7.0) -0.2439

GRAVY Index-0.60

Hydrophobic Moment 0.31

Boman Index0.07

Instability Index65.40

Aliphatic Index 45.88

Aromaticity 0.2941

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 873.90

LogP -6.73

H-bond Donors 29.0

H-bond Acceptors 29.0

Rotatable Bonds 65.0

Heavy Atoms 151.0

Ring Count 6.0

Amide Bonds 18.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0414334 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Confighydrocarbon-stapled side-chain cyclic peptide [Cyclic]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermFluorescein labeling

C-TermNone

Other ModsStapled: Ⓧ(4) and Ⓧ (8) are cross-linked by hydrocarbon stapling

Bio-Activity Profile

Function

Anticancer Antimicrobial Antibacterial

PaperCromm PM, Spiegel J, Küchler P, Dietrich L, Kriegesmann J, Wendt M, Goody RS, Waldmann H, Grossmann TN. Protease-Resistant and Cell-Permeable Double-Stapled Peptides Targeting the Rab8a GTPase. ACS Chem Biol. 2016 Aug 19;11(8):2375-104. PMID27336832 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27336832/