Peptide Database

Peptide NameGlucagon-like peptide 1

Function Ontology

Hormonal / Endocrine ▸ Hormone peptide

Metabolic

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Regulatory peptide ▸ Biological modulation

Regulatory peptide ▸ Biological regulation

Standard StatusStandard

Sequence Length37 amino acids

Chemical FormulaC185H273N51O60

DescriptionStandard

        HSEFERHAEGTYTSDITSYLEGQAAKEFIAWLVNGRG
    

Molecular Weight4171.45 Da

Isoelectric Point (pI)5.02

Net Charge (pH 7.0)-3.05

Net Charge (pH 7.4) -3.37

Charge Density (pH 7.0) -0.0825

GRAVY Index-0.63

Hydrophobic Moment 0.45

Boman Index-0.01

Instability Index12.53

Aliphatic Index 60.81

Aromaticity 0.1351

Extinction Coeff. Reduced 8480.00

Extinction Coeff. Oxidized 8480.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1805.71

LogP -18.95

H-bond Donors 64.0

H-bond Acceptors 59.0

Rotatable Bonds 136.0

Heavy Atoms 296.0

Ring Count 8.0

Amide Bonds 38.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0174041 VERIFIED: YES

Provenance & Taxonomy

OrganismGallus gallus [Animal]

FamilyGlucagon-like peptide

Tax ID9031

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other Mods36:Arginine amide

Bio-Activity Profile

Function

Hormone Endocrine Metabolic regulation Physiological regulation Receptor modulation

Half-LifeMammalian: 3.5 hour; Yeast: 10 min; E. coli: >10 hour

RECORD: Rec_0289985 VERIFIED: NO

Provenance & Taxonomy

OrganismGallus gallus [Animal]

FamilyGlucagon

Tax ID9031

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other ModsArg36 Amidation

Bio-Activity Profile

Function

Hormone Metabolic

RECORD: Rec_0362566 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide

Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/