Peptide Database

Peptide NameK6-10-A

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition ▸ Replication inhibitor

Enzyme modulation ▸ Enzyme inhibition ▸ Protease inhibition

Standard StatusStandard

Sequence Length18 amino acids

Chemical FormulaC89H131N21O27

DescriptionStandard

        GELGRPVYVLGDPGYYAT
    

Molecular Weight1927.12 Da

Isoelectric Point (pI)4.37

Net Charge (pH 7.0)-1.24

Net Charge (pH 7.4) -1.45

Charge Density (pH 7.0) -0.0688

GRAVY Index-0.17

Hydrophobic Moment 0.54

Boman Index0.20

Instability Index37.76

Aliphatic Index 81.11

Aromaticity 0.1667

Extinction Coeff. Reduced 4470.00

Extinction Coeff. Oxidized 4470.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 757.86

LogP -5.57

H-bond Donors 26.0

H-bond Acceptors 26.0

Rotatable Bonds 55.0

Heavy Atoms 137.0

Ring Count 5.0

Amide Bonds 17.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0088883 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilySynthetic peptide

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiviral Protease inhibitor Replication inhibitor

TargetHepatitis C virus (Replication); Escherichia coli

Activity0.2276 μM

MethodFRET assay

PaperHigh affinity peptide inhibitors of the hepatitis C virus NS3-4A protease refractory to common resistant mutants. | Kugler J, Schmelz S, Gentzsch J, Haid S, Pollmann E, van den Heuvel J, Franke R, Pietschmann T, Heinz DW, Collins J. | J Biol Chem. 2012 | PMID:22965230 PMID22965230 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22965230/

RECORD: Rec_0155838 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide; DSSP H 22.2%, E 0.0%, T 44.4%, C 33.3% [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Antimicrobial