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MYP_096553
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Basic Information
SR9EK1
Antimicrobial
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor
Enzyme modulation ▸ Enzyme inhibition ▸ Protease inhibition
Standard
35 amino acids
C188H328N50O61
Standard
Sequence
IEEINKKVEEIQKKIEELNKKAEELNKKLEELQKK
Physicochemical Analysis
4264.91 Da
6.49
-0.22
-0.46
-0.0063
-1.49
0.68
-0.43
114.73
100.29
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1901.37
-13.98
61.0
61.0
168.0
299.0
0.0
39.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0158768 VERIFIED: YES
Provenance & Taxonomy
Severe acute respiratory syndrome-related coronavirus [Virus]
HR2-derived fusion inhibitor
694009
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Severe acute respiratory syndrome coronavirus
100 μM
EC50
PaperHeptad repeat-derived peptides block protease-mediated direct entry from the cell surface of severe acute respiratory syndrome coronavirus but not entry via the endosomal pathway PMID17942557 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17942557/
RECORD: Rec_0193239 VERIFIED: YES
Provenance & Taxonomy
Severe acute respiratory syndrome-related coronavirus [Virus]
Virus-derived peptide
694009;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Entry inhibitor Fusion inhibitor Protease inhibitor
SARS coronavirus (Virus entry); Vero E6
100 μM
ELISA
PaperHeptad repeat-derived peptides block protease-mediated direct entry from the cell surface of severe acute respiratory syndrome coronavirus but not entry via the endosomal pathway. | Ujike M, Nishikawa H, Otaka A, Yamamoto N, Yamamoto N, Matsuoka M, Kodama E, Fujii N, Taguchi F. | J Virol. 2008 | PMID:17942557 PMID17942557 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17942557/
RECORD: Rec_0394459 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
SARS-CoV
PMID17942557 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17942557/
RECORD: Rec_0400015 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 77.1%, E 0.0%, T 14.3%, C 8.6% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/