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MYP_096519
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Basic Information
αs1-casein f(90_95)
Anticancer
Anticancer ▸ Anti-breast cancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid receptor ligand
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
6 amino acids
C38H57N9O9
Standard
Sequence
RYLGYL
Physicochemical Analysis
783.91 Da
8.59
0.76
0.55
0.1263
0.02
0.66
0.10
-18.38
130.00
0.3333
2980.00
2980.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
311.18
-0.29
12.0
10.0
23.0
56.0
2.0
5.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0266432 VERIFIED: YES
Provenance & Taxonomy
Bovine milk [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
PaperPubMed PMID: 23533710 PMID23533710 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23533710/
RECORD: Rec_0320612 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Casein-derived peptide
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Neuropeptide
acts as an opiate
70 μM
IC50
RECORD: Rec_0321943 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Casomorphin
9913
Structure & Mods
synthetic linear peptide [Linear]
all-D amino-acid peptide [D]
Bio-Activity Profile
Anticancer Cytotoxic Anti-breast cancer Cell-proliferative
decreased breastcancer cell proliferation
Cell proliferation assay
PaperAntiproliferative and receptor binding properties of α- and β-casomorphins in the T47D human breast cancer cell line | Hatzoglou, A. et al. | DOI: 10.1016/0014-2999(96)00339-1 Evidence URLhttps://www.uniprot.org/uniprotkb/P02662/entry
RECORD: Rec_0347798 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Casomorphin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
PaperHatzoglou A., Bakogeorgou E., Hatzoglou C., Martin P.-M., Castanas E.. Antiproliferative and receptor binding properties of alpha- and beta-casomorphins in the T47D human breast cancer cell line. Eur. J. Pharmacol., 310, 217-223, 1996.
RECORD: Rec_0421173 VERIFIED: YES
Provenance & Taxonomy
Bovine milk [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
PaperPubMed PMID: 23533710 PMID23533710 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23533710/
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