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MYP_096519
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Basic Information
αs1-casein f(90_95)
Anticancer
Anticancer ▸ Anti-breast cancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid receptor ligand
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
6 amino acids
C38H57N9O9
Standard
Sequence
RYLGYL
Physicochemical Analysis
783.91 Da
8.59
0.76
0.55
0.1263
0.02
0.66
0.10
-18.38
130.00
0.3333
2980.00
2980.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
311.18
-0.29
12.0
10.0
23.0
56.0
2.0
5.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0078190 VERIFIED: YES
Provenance & Taxonomy
Bovine milk [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
AZ-97 (Inhibition at 12-15 g/l)
PaperPubMed PMID: 23533710 PMID23533710 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23533710/
RECORD: Rec_0083775 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
9913;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Opioid
opioid receptor
PaperLoukas S., Varoucha D., Zioudrou C., Streaty R. A., Werner A. Klee W. A.. Opioid activities and structures of .alpha.-casein-derived exorphins. Biochemistry, 22, 4567-4573, 1983.
RECORD: Rec_0095444 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
alpha-S1-Casein-derived
9913
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Opioid receptor ligand
PaperOpioid activities and structures of α-casein-derived exorphins | Loukas, S. et al. | DOI: 10.1021/bi00288a034 Evidence URLhttps://www.uniprot.org/uniprotkb/P02662/entry
RECORD: Rec_0183000 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 0.0%, T 33.3%, C 66.7% [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer Antiviral Antihypertensive Antimicrobial Immunomodulatory Antioxidant
PaperCancerPPD: a database of anticancer peptides and proteins PMID25270878 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25270878/
RECORD: Rec_0200979 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Bovine milk
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antiviral Immunomodulatory Antihypertensive
AZ-97
12000-15000 μg/mL
Inhibition
PMID23533710 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23533710/
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