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MYP_096494
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Basic Information
Met-enkephalin
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral ▸ Anti-HIV
Cardiovascular
Delivery / Targeting ▸ Barrier transport ▸ Blood-brain barrier shuttle ▸ Blood-Brain Barrier
Delivery / Targeting ▸ Drug delivery vehicle
Enzyme modulation ▸ Enzyme inhibition ▸ DPP-III Inhibitory
Hormonal / Endocrine ▸ Hormone peptide
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Metabolic ▸ Appetite and feeding regulation ▸ Feeding regulator
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Analgesic
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid
Neurological / Signaling ▸ Analgesic/opioid activity ▸ opioid neuropeptide precursor family
Neurological / Signaling ▸ Neuromodulation
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide precursor
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide signaling
Neurological / Signaling ▸ Neuropeptide activity ▸ opioid neuropeptide precursor family
Neurological / Signaling ▸ Pain modulation ▸ Pronociceptive activity
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Biological regulation
Regulatory peptide ▸ Cell-cell communication
Regulatory peptide ▸ Cell signaling / Growth factor signaling ▸ Growth factor activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
5 amino acids
C27H35N5O7S
Standard
Sequence
YGGFM
Physicochemical Analysis
573.66 Da
5.52
-0.24
-0.45
-0.0482
0.52
0.17
0.61
15.70
0.00
0.4000
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
199.95
-0.46
7.0
8.0
16.0
40.0
2.0
4.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0250443 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Met-enkephalin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Analgesic Pronociceptive Hormone Endocrine Neuropeptide Neuromodulator Growth regulation Development regulation Receptor modulation
Experimental: 12.8 minutes; /768 seconds; Mammalian: 2.8 hour; Yeast: 10 min; E. coli: 2 min
PaperSource-linked PubMed record(s) for Met-enkephalin (Homo sapiens): PMID 3215483 PMID3215483 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/3215483/
RECORD: Rec_0252214 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
opioid neuropeptide precursor family
9606; 0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Neuropeptide opioid neuropeptide precursor family Growth factor signaling Hormone Neuropeptide signaling
PaperPDB 1PLX structural record; NMR; chain A; residues 1-5
RECORD: Rec_0260032 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Opioid peptide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Bio-Activity Profile
Neuropeptide Analgesic
Tris-HCl buffer with 0.156 mM sialorphin inhibitor
RP-HPLC
78 ± 2 min
PaperAlanine scan of sialorphin and its hybrids with opiorphin: synthesis, molecular modelling and effect on enkephalins degradation
RECORD: Rec_0262238 VERIFIED: YES
Provenance & Taxonomy
Loxodonta africana [Animal]
Met-enkephalin
9785
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hormone Endocrine Neuropeptide Neuromodulator
Experimental: 12.8 minutes; /768 seconds; Mammalian: 2.8 hour; Yeast: 10 min; E. coli: 2 min
PaperSource-linked PubMed record(s) for Met-enkephalin (Loxodonta africana): PMID 2854538##3215483 PMID2854538;3215483 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2854538/
RECORD: Rec_0283245 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Enkephalin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
PaperHorvat S, Mlinari?-Majerski K, Glavas-Obrovac L, Jakas A, Veljkovi? J, Marczi S, Kragol G, Rosci? M, Matkovi? M, Milosti?-Srb A.. Tumor-cell-targeted methionine-enkephalin analogues containing unnatural amino acids: design, synthesis, and in vitro antitumor activity. J. Med. Chem., 49, 3136-3142, 2006.
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