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MYP_096494
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Basic Information
Met-enkephalin
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral ▸ Anti-HIV
Cardiovascular
Delivery / Targeting ▸ Barrier transport ▸ Blood-brain barrier shuttle ▸ Blood-Brain Barrier
Delivery / Targeting ▸ Drug delivery vehicle
Enzyme modulation ▸ Enzyme inhibition ▸ DPP-III Inhibitory
Hormonal / Endocrine ▸ Hormone peptide
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Metabolic ▸ Appetite and feeding regulation ▸ Feeding regulator
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Analgesic
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid
Neurological / Signaling ▸ Analgesic/opioid activity ▸ opioid neuropeptide precursor family
Neurological / Signaling ▸ Neuromodulation
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide precursor
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide signaling
Neurological / Signaling ▸ Neuropeptide activity ▸ opioid neuropeptide precursor family
Neurological / Signaling ▸ Pain modulation ▸ Pronociceptive activity
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Biological regulation
Regulatory peptide ▸ Cell-cell communication
Regulatory peptide ▸ Cell signaling / Growth factor signaling ▸ Growth factor activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
5 amino acids
C27H35N5O7S
Standard
Sequence
YGGFM
Physicochemical Analysis
573.66 Da
5.52
-0.24
-0.45
-0.0482
0.52
0.17
0.61
15.70
0.00
0.4000
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
199.95
-0.46
7.0
8.0
16.0
40.0
2.0
4.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0318328 VERIFIED: YES
Provenance & Taxonomy
The native [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
HBL , 1% inhibition at 10μM, 4.5% inhibition at 100μM, 10.8% inhibition at 1000μM
0.4 %
Inhibition
PaperTumor-cell-targeted methionine-enkephalin analogues containing unnatural amino acids: design, synthesis, and in vitro antitumor activity. J Med Chem. 2006 Jun 1;49(11):3136-42. doi: 10.1021/jm051026+. PMID: 16722632. PMID16722632 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16722632/
RECORD: Rec_0326931 VERIFIED: YES
Provenance & Taxonomy
Macaca nemestrina [Animal]
Met-enkephalin
9545
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hormone Endocrine Neuropeptide Neuromodulator
Experimental: 12.8 minutes; /768 seconds; Mammalian: 2.8 hour; Yeast: 10 min; E. coli: 2 min
PaperSource-linked PubMed record(s) for Met-enkephalin (Macaca nemestrina): PMID 3229286##3215483 PMID3229286;3215483 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/3229286/
RECORD: Rec_0334983 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Enkephalin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Neurotransmitter
TLC (Thin-layer chromatography)
Human plasma, in vitro; 768 s
PMID3215483 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/3215483/
RECORD: Rec_0339690 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Opioid peptide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Bio-Activity Profile
Neuropeptide Analgesic
Tris-HCl buffer with 0.156 mM [Ala1]sialorphin inhibitor
RP-HPLC
47 ± 1 min
PaperAlanine scan of sialorphin and its hybrids with opiorphin: synthesis, molecular modelling and effect on enkephalins degradation
RECORD: Rec_0352704 VERIFIED: YES
Provenance & Taxonomy
The native [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
HT-29 , 15.9% inhibition at 10μM, 16.1% inhibition at 100μM, 19.3% inhibition at 1000μM
14 %
Inhibition
PaperTumor-cell-targeted methionine-enkephalin analogues containing unnatural amino acids: design, synthesis, and in vitro antitumor activity. J Med Chem. 2006 Jun 1;49(11):3136-42. doi: 10.1021/jm051026+. PMID: 16722632. PMID16722632 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16722632/
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