Peptide Database

Peptide Name[Y8S-I11S]cTI

Function Ontology

Anticancer

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length18 amino acids

Chemical FormulaC92H147N35O22S4

DescriptionStandard

        KWCFRVCSRGSCYRRCRG
    

Molecular Weight2223.63 Da

Isoelectric Point (pI)10.16

Net Charge (pH 7.0)5.72

Net Charge (pH 7.4) 5.45

Charge Density (pH 7.0) 0.3177

GRAVY Index-0.78

Hydrophobic Moment 0.59

Boman Index-0.50

Instability Index51.25

Aliphatic Index 16.11

Aromaticity 0.1667

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 7240.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 970.02

LogP -11.38

H-bond Donors 43.0

H-bond Acceptors 32.0

Rotatable Bonds 72.0

Heavy Atoms 153.0

Ring Count 4.0

Amide Bonds 17.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0332123 VERIFIED: YES

Provenance & Taxonomy

Organismhost defense peptide from the horseshoe crab Tachypleus tridentatus [other]

Structure & Mods

Configcyclic/stapled peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Anticancer

TargetMDA-MB-435S

Activity>32 μM

MethodCC50

RECORD: Rec_0419217 VERIFIED: YES