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MYP_096465
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Basic Information
Brevinin-1PRa
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Standard
24 amino acids
C122H211N27O29S2
Standard
Sequence
FLPVLTGLTPSIVPKLVCLLTKKC
Physicochemical Analysis
2584.27 Da
9.39
2.74
2.50
0.1141
1.16
0.52
0.36
39.10
150.00
0.0417
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
865.23
-3.39
31.0
34.0
81.0
180.0
4.0
23.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0001293 VERIFIED: YES
Provenance & Taxonomy
Rana pretiosa [Animal]
Brevinin
69834
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
18-24
Bio-Activity Profile
Antimicrobial Antifungal
Escherichia coli
>100 μM
MIC
PaperHost defense peptides in skin secretions of the Oregon spotted frog Ranapretiosa: implications for species resistance to chytridiomycosis
RECORD: Rec_0012133 VERIFIED: YES
Provenance & Taxonomy
Oregon spotted [Animal]
Brevinin
33208
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
18-24
Bio-Activity Profile
Antimicrobial
PMID17049601 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17049601/
RECORD: Rec_0035159 VERIFIED: YES
Provenance & Taxonomy
Rana luteiventris [Animal]
Brevinin
Structure & Mods
DNA-encoded linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0039106 VERIFIED: YES
Provenance & Taxonomy
Rana pretiosa [Animal]
Brevinin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
18-24
Bio-Activity Profile
Hemolytic Cytolytic
Erythrocytes
150.0 μM
HC50
PaperJ.M. Conlon et al. / Developmental and Comparative Immunology 35 (2011) 644-649. Host defense peptides in skin secretions of the Oregon spotted frog Rana pretiosa: implications for species resistance to chytridiomycosis PMID21295070 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21295070/
RECORD: Rec_0040709 VERIFIED: YES
Provenance & Taxonomy
Rana pretiosa [Animal]
Brevinin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
18-24
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
50.0 μM
MIC
PaperJ.M. Conlon et al. / Developmental and Comparative Immunology 35 (2011) 644-649. Host defense peptides in skin secretions of the Oregon spotted frog Rana pretiosa: implications for species resistance to chytridiomycosis PMID21295070 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21295070/
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