Peptide Database

Peptide NameRopeginterferon alfa-2b

Function Ontology

Anticancer

Immunology ▸ Immune modulation ▸ Immunomodulatory activity

Therapeutic / Biomedical activity ▸ Enzyme replacement therapy

Standard StatusStandard

Sequence Length166 amino acids

Chemical FormulaC865H1360N230O256S9

DescriptionStandard

        PCDLPQTHSLGSRRTLMLLAQMRRISLFSCLKDRHDFGFPQEEFGNQFQKAETIPVLHEMIQQIFNLFSTKDSSAAWDETLLDKFYTELYQQLNDLEACVIQGVGVTETPLMKEDSILAVRKYFQRITLYLKEKKYSPCAWEVVRAEIMRSFSLSTNLQESLRSKE
    

Molecular Weight19366.02 Da

Isoelectric Point (pI)5.99

Net Charge (pH 7.0)-1.78

Net Charge (pH 7.4) -2.10

Charge Density (pH 7.0) -0.0107

GRAVY Index-0.35

Hydrophobic Moment 0.62

Boman Index-0.04

Instability Index53.22

Aliphatic Index 85.18

Aromaticity 0.1024

Extinction Coeff. Reduced 18450.00

Extinction Coeff. Oxidized 18700.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 7900.41

LogP -76.85

H-bond Donors 278.0

H-bond Acceptors 266.0

Rotatable Bonds 656.0

Heavy Atoms 1360.0

Ring Count 28.0

Amide Bonds 181.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0342027 VERIFIED: NO

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyInterferon

Tax ID32630

Structure & Mods

Configlinear peptide/protein therapeutic [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other ModsPEGylation, Lipidation

Bio-Activity Profile

Function

Immunomodulatory Enzyme replacement

Half-LifeRopeginterferon alfa-2b administered to polycythemia vera patients over a dose range of 100-500 µg has a half-life of approximately seven days.[L39170]

RECORD: Rec_0379953 VERIFIED: NO

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyInterferon

Tax ID32630

Structure & Mods

Configlinear peptide/protein therapeutic [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other ModsPEGylation, Lipidation

Bio-Activity Profile

Function

Anticancer Immunomodulatory

Half-LifeRopeginterferon alfa-2b administered to polycythemia vera patients over a dose range of 100-500 µg has a half-life of approximately seven days.[L39170]

RECORD: Rec_0386909 VERIFIED: NO

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyInterferon

Tax ID32630

Structure & Mods

Configlinear peptide/protein therapeutic [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other ModsPEGylation, Lipidation

Bio-Activity Profile

Function

Immunomodulatory

Half-LifeRopeginterferon alfa-2b administered to polycythemia vera patients over a dose range of 100-500 µg has a half-life of approximately seven days.[L39170]