Peptide Database

Peptide NameBeta-defensin 4 (BD-4) (BD-2) (Defensin; beta 4) (RBD-2) (RBD-4)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Immunology ▸ Immune cell migration ▸ Chemotactic peptide

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length63 amino acids

Chemical FormulaC313H506N86O78S7

DescriptionStandard

        MRIHYLLFSFLLVLLSPLSAFTQSINNPITCLTKGGVCWGPCTGGFRQIGTCGLPRVRCCKKK
    

Molecular Weight6946.35 Da

Isoelectric Point (pI)9.77

Net Charge (pH 7.0)7.52

Net Charge (pH 7.4) 7.16

Charge Density (pH 7.0) 0.1194

GRAVY Index0.41

Hydrophobic Moment 0.54

Boman Index0.16

Instability Index43.81

Aliphatic Index 95.87

Aromaticity 0.0952

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 7365.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2603.17

LogP -22.85

H-bond Donors 98.0

H-bond Acceptors 94.0

Rotatable Bonds 224.0

Heavy Atoms 484.0

Ring Count 12.0

Amide Bonds 66.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0174256 VERIFIED: YES

Provenance & Taxonomy

OrganismRattus norvegicus [Animal]

FamilyBeta-defensin; Defensin

Tax ID10116

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Defensin Anti-Gram-negative Anti-Gram-positive Chemotactic Non-hemolytic

TargetGram Negative Bacteria and Gram Positive Bacteria