Peptide Database

Peptide NameSLAY-screened peptide P1149

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length10 amino acids

Chemical FormulaC53H71N13O12S2

DescriptionStandard

        WPPCGSHCLF
    

Molecular Weight1146.34 Da

Isoelectric Point (pI)6.72

Net Charge (pH 7.0)-0.17

Net Charge (pH 7.4) -0.45

Charge Density (pH 7.0) -0.0173

GRAVY Index0.31

Hydrophobic Moment 0.15

Boman Index0.38

Instability Index39.98

Aliphatic Index 39.00

Aromaticity 0.2000

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5625.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 372.34

LogP -1.76

H-bond Donors 14.0

H-bond Acceptors 15.0

Rotatable Bonds 28.0

Heavy Atoms 80.0

Ring Count 6.0

Amide Bonds 9.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0149161 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/