Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length434 amino acids

Chemical FormulaC2185H3497N601O606S10

DescriptionStandard

        AHQQAIAFLEKELAQLKLPDISGDFRIKPVGKVRYEISRLELQSFHLPYSRISLVPNVGLQVSISNAFAEVDGNWRVKVLFIKDHGSFDLRVDNVYIKINLKLGSDASGKPTIDTSDCSTSISSVRVHFSGRLGWLYNLFYNAIESRFRKILERKVCDSVARSVRGELQTYLQTLPVTARIDNRVGIDYSLVAPPTATTQSLDADLKGEFFSLAQRSAVPFPPLPLAFPPDHGLGRLCQRGAVGWRLRDGGRRADFTVRLVELHGPSMTVLLLQIPKGIEFHLNTTTFSAFVPQLDKIYPEMPMKLRLSAPSAPFLNIGPEGLSLKPVVDIQAYAILPNSSLVPLFLLNVTSNVSAMIDVKSGHIVGNLKVGRMKLSLKHSDVGPFQVRPLQSIMNVVASSILLPRLNARLDEGFPLPLPDRIQLSNILMRFHQ
    

Molecular Weight48202.45 Da

Isoelectric Point (pI)9.68

Net Charge (pH 7.0)13.67

Net Charge (pH 7.4) 12.85

Charge Density (pH 7.0) 0.0315

GRAVY Index0.03

Hydrophobic Moment 0.83

Boman Index0.07

Instability Index37.28

Aliphatic Index 106.43

Aromaticity 0.0783

Extinction Coeff. Reduced 29910.00

Extinction Coeff. Oxidized 30035.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0121197 VERIFIED: NO

Provenance & Taxonomy

OrganismApaloderma vittatum [other]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria