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MYP_096244
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Basic Information
P72(derived from HCV polyprotein)
Antimicrobial
Antiviral
Antiviral ▸ Anti-Hepatitis virus ▸ Anti-HCV
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Enzyme modulation ▸ Enzyme inhibition ▸ Protease inhibition
Standard
13 amino acids
C69H121N17O18
Standard
Sequence
KKKKEVAATYVLV
Physicochemical Analysis
1476.80 Da
9.83
2.76
2.55
0.2121
-0.08
0.20
-0.08
9.23
112.31
0.0769
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
594.36
-3.02
21.0
21.0
52.0
104.0
1.0
12.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0048191 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral Anti-HCV NS3 protease inhibitor Protease inhibition
Hepatitis C virus NS3-6K protease
2 %
fluorescence-based NS3-6K protease inhibition assay
PaperPeptide inhibitors of hepatitis C virus NS3 protease. Antivir Chem Chemother. 2003 Sep;14(5):225-33. doi: 10.1177/095632020301400501. PMID: 14694985. PMID14694985 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14694985/
RECORD: Rec_0188041 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HCV Replication inhibition NS3 protease inhibitor Protease inhibition
Hepatitis C virus NS3-6K protease
2 %
NS3-6K protease inhibition at 3 μM
Mammalian: 1.3 h; Yeast: 3 min; E. coli: 2 min
PaperPeptide inhibitors of hepatitis C virus NS3 protease. | Portal-Núñez S, González-Navarro CJ, García-Delgado M, Vizmanos JL, Lasarte JJ, Borrás-Cuesta F. | Antivir Chem Chemother. 2003 Sep;14(5):225-33. | DOI:10.1177/095632020301400501 | PMID:14694985 PMID14694985 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14694985/
RECORD: Rec_0251209 VERIFIED: YES
Provenance & Taxonomy
synthetic construct derived from Hepatitis C virus [Synthetic]
Virus-derived peptide
3052230;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Protease inhibitor Anti-HCV NS3 protease inhibitor Protease inhibition
Hepatitis C virus NS3-6K protease
2 %
fluorescence-based NS3-6K protease inhibition assay
PaperPeptide inhibitors of hepatitis C virus NS3 protease. | Portal-Nunez S, Gonzalez-Navarro CJ, Garcia-Delgado M, Vizmanos JL, Lasarte JJ, Borras-Cuesta F. | Antivir Chem Chemother. 2003 | PMID:14694985 PMID14694985 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14694985/
RECORD: Rec_0302355 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral Anti-HCV NS3 protease inhibitor Protease inhibition
PaperPeptide inhibitors of hepatitis C virus NS3 protease. Antivir Chem Chemother. 2003 Sep;14(5):225-33. doi: 10.1177/095632020301400501. PMID: 14694985. PMID14694985 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14694985/
RECORD: Rec_0380675 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/