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MYP_096182
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Basic Information
Psyle C
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
25 amino acids
C126H187N29O34S6
Standard
Sequence
KLCGETCFKFKCYTPGCSCSYPFCK
Physicochemical Analysis
2844.40 Da
8.64
2.70
2.40
0.1079
-0.06
0.28
0.04
13.45
15.60
0.2000
2980.00
3355.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1006.90
-9.31
41.0
43.0
88.0
195.0
7.0
24.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0253098 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 0.0%, T 64.0%, C 36.0% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Anticancer Antibacterial Antimicrobial
PaperCancerPPD: a database of anticancer peptides and proteins PMID25270878 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25270878/
RECORD: Rec_0296447 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
RECORD: Rec_0302394 VERIFIED: YES
Provenance & Taxonomy
Psychotria leptothyrsa [Plant]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
This is the shortest acyclic variant of cyclotides in this series. Psyle C is most hydrophilic in this series of cyclotides. Anticancer assay: human lymphoma cell line U937-GTB
3.5 μM
IC50
PaperIsolation, characterization, and bioactivity of cyclotides from the Micronesian plant Psychotria leptothyrsa.
RECORD: Rec_0304951 VERIFIED: YES
Provenance & Taxonomy
Psychotria leptothyrsa [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Cytotoxic
Lymphoma cell line
3.50 μM
IC50
RECORD: Rec_0360961 VERIFIED: YES
Provenance & Taxonomy
Psychotria leptothyrsa [Plant]
Psychotria leptothyrsa
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial
PMID20575512;18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20575512/
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