Peptide Database

Peptide NameCarnolysin

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Standard StatusStandard

Sequence Length45 amino acids

Chemical FormulaC184H305N51O62S4

DescriptionStandard

        GDINGEFTTSPACVYSVMVVSKASSAKCAAGASAVSGAILSAIRC
    

Molecular Weight4351.95 Da

Isoelectric Point (pI)7.94

Net Charge (pH 7.0)0.73

Net Charge (pH 7.4) 0.48

Charge Density (pH 7.0) 0.0163

GRAVY Index0.70

Hydrophobic Moment 0.46

Boman Index0.26

Instability Index30.01

Aliphatic Index 86.89

Aromaticity 0.0444

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1615.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1789.09

LogP -25.43

H-bond Donors 67.0

H-bond Acceptors 67.0

Rotatable Bonds 140.0

Heavy Atoms 301.0

Ring Count 3.0

Amide Bonds 45.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0103848 VERIFIED: YES

Provenance & Taxonomy

OrganismCarnobacterium maltaromaticum [Bacterium]

FamilyBacteriocin

Structure & Mods

Configlinear peptide [Linear]

Chiralitymixed L/D amino-acid peptide [Mixed]

Other ModsThis is a two-component lantibiotic. The sequence of Carnolysin A1 is provided in the sequence field. The sequence of Carnolysin A2 is GDVMPESTPICAGFATLMSSIGLVKTIKGKC. Both sequences are processed after post-translation. Altogether, there are six dehydrated ser or thr, and five thioether bonds in the two chains. For Carnolysin A1, residues 8, 10, and 25 are dehydrated; thioether bonds exist between residues 9, 13; 24,28; 41,45; residues 16, 21, 33, 36, are D-amino acids. For Carnolysin A2, residues 8, 16, and 20 are dehydrated; thioether bonds exist between 7, 11; 26, 31; residues 16 and 19 are D-amino acids, which is the first D-Abu in ribosomally synthesized peptide (Lohans CT et al. 2014). However, further processing appeared to be required to generate active peptides, for example, digestion with endoproteinase GluC

Bio-Activity Profile

Function

Antimicrobial

TargetL. lactis

RECORD: Rec_0256410 VERIFIED: YES

Provenance & Taxonomy

OrganismBacteria [Bacterium]

Tax ID2

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other ModsPaclitaxel conjugation

Bio-Activity Profile

Function

Antimicrobial

RECORD: Rec_0316318 VERIFIED: YES

Provenance & Taxonomy

OrganismCarnobacterium maltaromaticum [Bacterium]

FamilyBacteriocin

Structure & Mods

Configtopology not specified [Not included yet]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive

TargetGram-positive(broad)