Peptide Database

Peptide NamePotassium channel toxin alpha-KTx 1.12 (Charybdotoxin b) (ChTx-b)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Antimicrobial ▸ Antifungal ▸ Anti-Candida

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Toxin

Standard StatusStandard

Sequence Length59 amino acids

Chemical FormulaC287H472N78O83S9

DescriptionStandard

        MKILSVLLLALIICSIVGWSEAQFTDVSCTTSKECWSVCQRLHNTSIGKCMNKKCRCYS
    

Molecular Weight6631.88 Da

Isoelectric Point (pI)8.79

Net Charge (pH 7.0)3.52

Net Charge (pH 7.4) 3.14

Charge Density (pH 7.0) 0.0596

GRAVY Index0.35

Hydrophobic Moment 0.60

Boman Index0.10

Instability Index44.76

Aliphatic Index 95.76

Aromaticity 0.0678

Extinction Coeff. Reduced 12490.00

Extinction Coeff. Oxidized 12865.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2612.53

LogP -26.31

H-bond Donors 101.0

H-bond Acceptors 97.0

Rotatable Bonds 224.0

Heavy Atoms 457.0

Ring Count 7.0

Amide Bonds 62.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0111746 VERIFIED: YES

Provenance & Taxonomy

OrganismLeiurus hebraeus [Animal]

FamilyShort scorpion toxin; Potassium channel inhibitor; Alpha-KTx 01 subfamily

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Toxin Non-hemolytic

TargetStaphylococcus aureus

RECORD: Rec_0382465 VERIFIED: YES

Provenance & Taxonomy

OrganismLeiurus hebraeus [Animal]

FamilyShort scorpion toxin; Potassium channel inhibitor; Alpha-KTx 01 subfamily

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Toxin Non-hemolytic

TargetEscherichia coli

RECORD: Rec_0407814 VERIFIED: YES

Provenance & Taxonomy

OrganismLeiurus hebraeus [Animal]

FamilyShort scorpion toxin; Potassium channel inhibitor; Alpha-KTx 01 subfamily

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Toxin Non-hemolytic

TargetBacillus subtilis