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MYP_096085
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Basic Information
Cliotide T2
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
30 amino acids
C130H222N38O40S6
Standard
Sequence
GSVIKCGESCLLGKCYTPGCTCSRPICKKN
Physicochemical Analysis
3149.77 Da
8.90
3.70
3.40
0.1233
-0.04
0.51
-0.02
46.08
61.67
0.0333
1490.00
1865.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1257.39
-16.38
50.0
50.0
104.0
214.0
3.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0030253 VERIFIED: YES
Provenance & Taxonomy
Clitoria ternatea [Plant]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anti-Gram-negative
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0103763 VERIFIED: YES
Provenance & Taxonomy
Clitoria ternatea [Plant]
Cyclotide
43366
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
20 μM
MIC
PaperImmunostimulating and Gram-negative-specific antibacterial cyclotides from the butterfly pea (Clitoria ternatea) | Gilding et al., 2016 PMID27007913 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27007913/
RECORD: Rec_0149607 VERIFIED: YES
Provenance & Taxonomy
Clitoria ternatea [Animal]
Cyclotide
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibiotic Defense peptide Anti-Gram-negative Anti-Gram-positive Cytotoxic Non-hemolytic
Escherichia coli (Gram-negative)
PMID27007913 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27007913/
RECORD: Rec_0149808 VERIFIED: NO
Provenance & Taxonomy
Clitoria ternatea [Plant]
Cyclotide
43366
Structure & Mods
backbone-cyclized cyclotide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PaperCliotide T19 (Cyclotide cT19) Evidence URLhttps://www.uniprot.org/uniprotkb/C0HJS6/entry
RECORD: Rec_0246056 VERIFIED: YES
Provenance & Taxonomy
Clitoria ternatea [Plant]
Cyclotide
43366
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
PaperImmunostimulating and Gram-negative-specific antibacterial cyclotides from the butterfly pea (Clitoria ternatea) | Gilding et al., 2016 PMID27007913 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27007913/
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