Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length474 amino acids

Chemical FormulaC2333H3664N594O695S12

DescriptionStandard

        MRLFLAVIVLITPTSGETPAVHVSLTDKALHYGAYAGAQWMTDKLKDVSIPDISGEIYILFDNLHYTLMGITIENVKFPEPSVEFYPGRGLDASVSDVSVTLTGGWITRFGLIQDGGTFQMNVFNTDVTFAVQLGRGVGGHPFVTSVNCEAHVGGVDMQFHGGASWIFQPFVSKYRDRVRGEIEDKICPQLEESIIKLDYRLQVFGVSINVSKDLTLDLGLTDDPVIDVSSLNVGLKGVIYSIKTHAEPPFAPQPFSLAEQPDSMLTLGVSEFTLNSASYAYYSAGLLQILLNDSMIPSYSPVHLNTSSFGAFIPQLPKMYPGLLMNLQLYAREVPVVSFQPGLVTLDLQGAVKAYAIQLTGAQIPLFTLNTDSKFSGKVWTAGGRLKGSAEMKNLTVTLQATEIGGFETAALENLARVGAKLAITKLNQRLRKGVELPRLKHAELTNTTLEVETGFITISTDAQISLTEDSTD
    

Molecular Weight51538.39 Da

Isoelectric Point (pI)5.13

Net Charge (pH 7.0)-13.67

Net Charge (pH 7.4) -14.48

Charge Density (pH 7.0) -0.0288

GRAVY Index0.11

Hydrophobic Moment 0.71

Boman Index0.16

Instability Index32.34

Aliphatic Index 99.73

Aromaticity 0.0886

Extinction Coeff. Reduced 44350.00

Extinction Coeff. Oxidized 44475.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0391811 VERIFIED: NO

Provenance & Taxonomy

OrganismTakifugu bimaculatus [Bacterium]

FamilyBPI

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence