Peptide Database

Peptide NameSapecin-B

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length88 amino acids

Chemical FormulaC436H731N127O125S9

DescriptionStandard

        MKFLTSLLLLFVVVMVSAVNLSMAKESANQLTERLQELDGAAIQEPAELNRHKRLTCEIDRSLCLLHCRLKGYLRAYCSQQKVCRCVQ
    

Molecular Weight10040.83 Da

Isoelectric Point (pI)8.86

Net Charge (pH 7.0)3.63

Net Charge (pH 7.4) 3.20

Charge Density (pH 7.0) 0.0412

GRAVY Index0.11

Hydrophobic Moment 0.73

Boman Index-0.02

Instability Index45.25

Aliphatic Index 110.80

Aromaticity 0.0455

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 3355.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 4115.73

LogP -38.00

H-bond Donors 150.0

H-bond Acceptors 140.0

Rotatable Bonds 347.0

Heavy Atoms 697.0

Ring Count 7.0

Amide Bonds 96.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0219371 VERIFIED: YES

Provenance & Taxonomy

OrganismSarcophaga peregrina [Animal]

FamilyDefensin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidedisulfide bond; sites not specified

Bio-Activity Profile

Function

Antimicrobial Defensin Anti-Gram-positive Cytotoxic Non-hemolytic

TargetGram-positive bacteria

RECORD: Rec_0289587 VERIFIED: YES