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MYP_095993
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Basic Information
Unnamed
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Enzyme modulation ▸ Enzyme inhibition ▸ Integrase inhibition
Standard
6 amino acids
C46H55N11O7S
Standard
Sequence
HCKFWW
Physicochemical Analysis
906.06 Da
8.23
0.84
0.57
0.1394
-0.60
0.29
0.20
8.33
0.00
0.5000
11000.00
11000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
295.10
1.54
12.0
10.0
24.0
65.0
6.0
5.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0114120 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
branched peptide architecture [Branched]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Integrase inhibition
90 μM
IC50
PaperDesign and synthesis of dimeric HIV-1 integrase inhibitory peptides. PMID12951093 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12951093/
RECORD: Rec_0125254 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antiviral Anti-HIV-1 Replication inhibition
HIV-1
2 μM
IC50
Mammalian: 3.5 h; Yeast: 10 min; E. coli: >10 h
PaperIdentification of a hexapeptide inhibitor of the human immunodeficiency virus integrase protein by using a combinatorial chemical library. | Puras Lutzke RA, Eppens NA, Weber PA, Houghten RA, Plasterk RH. | Proc Natl Acad Sci U S A. 1995 Dec 5;92(25):11456-60. | DOI:10.1073/pnas.92.25.11456 | PMID:8524782 PMID8524782 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8524782/
RECORD: Rec_0170498 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperHIPdb: a database of experimentally validated HIV inhibiting peptides PMID23359817 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23359817/
RECORD: Rec_0215177 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Integrase inhibition
E.coli
2 μM
IC50
PaperViral integrase inhibiting peptides PatentUS5578573
RECORD: Rec_0221010 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Integrase inhibition
100 %
Inhibition
PaperIdentification of a hexapeptide inhibitor of the human immunodeficiency virus integrase protein by using a combinatorial chemical library. PMID8524782 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8524782/
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