Peptide Database

Peptide NameCyclotide varv Hm

Function Ontology

Anticancer

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length30 amino acids

Chemical FormulaC126H194N36O43S7

DescriptionStandard

        CLPVCGETCFGGTCNTPGCSCETWPVCSRN
    

Molecular Weight3125.56 Da

Isoelectric Point (pI)4.53

Net Charge (pH 7.0)-1.30

Net Charge (pH 7.4) -1.61

Charge Density (pH 7.0) -0.0435

GRAVY Index0.08

Hydrophobic Moment 0.29

Boman Index0.11

Instability Index47.68

Aliphatic Index 32.33

Aromaticity 0.0667

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5875.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1240.70

LogP -18.41

H-bond Donors 49.0

H-bond Acceptors 49.0

Rotatable Bonds 91.0

Heavy Atoms 212.0

Ring Count 6.0

Amide Bonds 31.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0212415 VERIFIED: YES

Provenance & Taxonomy

OrganismViola tricolor [Plant]

FamilyCyclotide

Tax ID214053

Structure & Mods

Confighead-to-tail cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidemultiple disulfide bonds reported, sites not specified

Bio-Activity Profile

Function

Antimicrobial Anticancer Cytotoxic