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MYP_095913
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Basic Information
SARS-CoV S (483-494), SP-8
Antimicrobial
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV
Antiviral ▸ Antiviral mechanism ▸ Pseudovirus inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Standard
12 amino acids
C68H91N13O20
Standard
Sequence
FYTTTGIGYQPY
Physicochemical Analysis
1410.53 Da
5.52
-0.24
-0.45
-0.0202
-0.38
0.14
0.29
24.08
32.50
0.3333
4470.00
4470.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
539.10
-3.96
19.0
20.0
38.0
101.0
5.0
12.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0007000 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 16337697 PMID16337697 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16337697/
RECORD: Rec_0147308 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-SARS-COV Pseudovirus inhibition
SARS-CoV | Vero cells
0.00699±0.00071 μM
IC50
Mammalian: 1.1 h; Yeast: 3 min; E. coli: 2 min
PaperDesign and biological activities of novel inhibitory peptides for SARS-CoV spike protein and angiotensin-converting enzyme 2 interaction. | Ho TY, Wu SL, Chen JC, Wei YC, Cheng SE, Chang YH, Liu HJ, Hsiang CY. | Antiviral Res. 2006 Feb;69(2):70-6. | DOI:10.1016/j.antiviral.2005.10.005 | PMID:16337697 PMID16337697 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16337697/
RECORD: Rec_0299373 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
SARS-CoV:Inhibition of pseudovirus infection in Vero cells
0.00699±0.00071 μM
IC50
PaperPubMed PMID: 16337697 PMID16337697 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16337697/
RECORD: Rec_0423681 VERIFIED: YES
Provenance & Taxonomy
Severe acute respiratory syndrome-related coronavirus [Virus]
Synthetic antiviral peptide
694009
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Severe acute respiratory syndrome coronavirus
0.00699 μM
IC50
PaperDesign and biological activities of novel inhibitory peptides for SARS-CoV spike protein and angiotensin-converting enzyme 2 interaction PMID16337697 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16337697/