Peptide Database

Peptide NameThiocillin GE37468 (Bacteriocin)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Standard StatusStandard

Sequence Length14 amino acids

Chemical FormulaC59H89N15O22S5

DescriptionStandard

        STNCFCYICCSCSS
    

Molecular Weight1520.75 Da

Isoelectric Point (pI)5.23

Net Charge (pH 7.0)-0.59

Net Charge (pH 7.4) -0.87

Charge Density (pH 7.0) -0.0422

GRAVY Index0.79

Hydrophobic Moment 0.26

Boman Index0.20

Instability Index33.54

Aliphatic Index 27.86

Aromaticity 0.1429

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1740.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 606.09

LogP -10.19

H-bond Donors 27.0

H-bond Acceptors 27.0

Rotatable Bonds 45.0

Heavy Atoms 101.0

Ring Count 2.0

Amide Bonds 14.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0139120 VERIFIED: YES

Provenance & Taxonomy

OrganismStreptomyces ATCC 55365 [Bacterium]

FamilyBacteriocin

Structure & Mods

Configtopology not specified [Not included yet]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative

TargetGram-negative

RECORD: Rec_0298055 VERIFIED: YES

Provenance & Taxonomy

OrganismStreptomyces sp. [Bacterium]

FamilyBacteriocin

Structure & Mods

Configcyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermCyclization

C-TermNone

Other Mods①GE37468 has a macrocyclic ring composed of 10 residues (Ser1 to Cys10). ②Cys6 converts to a thiazoline while four other Cys residues (Cys4, Cys9, Cys10 and Cys12) are fully desaturated to thiazoles in GE37468. ③Ile8 converts to β-methyl-δ-hydroxy-proline(mhP) through a predicted tandem double hydroxylation/cyclization mechanism

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive

TargetStaphylococcus aureus (MRSA)

Activity0.047 μg/mL

MethodMIC

RECORD: Rec_0308903 VERIFIED: YES

Provenance & Taxonomy

OrganismStreptomyces sp. [Bacterium]

FamilyBacteriocin

Structure & Mods

Configcyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermCyclization

C-TermNone

Other Mods①GE37468 has a macrocyclic ring composed of 10 residues (Ser1 to Cys10). ②Cys6 converts to a thiazoline while four other Cys residues (Cys4, Cys9, Cys10 and Cys12) are fully desaturated to thiazoles in GE37468. ③Ile8 converts to β-methyl-δ-hydroxy-proline(mhP) through a predicted tandem double hydroxylation/cyclization mechanism

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive

TargetBacillus subtilis

Activity0.047 μg/mL

MethodMIC

RECORD: Rec_0426545 VERIFIED: YES

Provenance & Taxonomy

OrganismStreptomyces ATCC 55365 [Bacterium]

FamilyBacteriocin

Structure & Mods

Configtopology not specified [Not included yet]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative

TargetGram-positive