Peptide Database

Peptide NameSLAY-screened peptide P5541

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length21 amino acids

Chemical FormulaC105H177N23O26S3

DescriptionStandard

        IQCMSPVVVPLILFTILGCLN
    

Molecular Weight2273.86 Da

Isoelectric Point (pI)5.51

Net Charge (pH 7.0)-0.26

Net Charge (pH 7.4) -0.49

Charge Density (pH 7.0) -0.0124

GRAVY Index1.85

Hydrophobic Moment 0.32

Boman Index0.61

Instability Index109.16

Aliphatic Index 171.43

Aromaticity 0.0476

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 754.38

LogP -2.60

H-bond Donors 26.0

H-bond Acceptors 29.0

Rotatable Bonds 70.0

Heavy Atoms 157.0

Ring Count 3.0

Amide Bonds 22.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0362292 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/