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MYP_095753
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Basic Information
Gaegurin-1 (Gaegurin 1; GGN1; Frogs, amphibians, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
33 amino acids
C155H258N42O41S3
Standard
Sequence
SLFSLIKAGAKFLGKNLLKQGACYAACKASKQC
Physicochemical Analysis
3462.16 Da
9.74
5.42
5.16
0.1643
0.26
0.60
0.10
42.68
89.09
0.0909
1490.00
1615.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1360.83
-13.42
50.0
50.0
121.0
241.0
3.0
35.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0171931 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Evidence URLhttps://patents.google.com/patent/US20080170991A1/en PatentUS 2008/0170991 A1
RECORD: Rec_0174611 VERIFIED: YES
Provenance & Taxonomy
Rana rugosa [Animal]
Gaegurin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antiparasitic
Staphylococcus epidermidis, Bacillus subtilis, P. putida, Pseudomonas aeruginosa
50 μg/mL
MIC
PaperAntimicrobial peptides from the skin of a Korean frog, Rana rugosa.
RECORD: Rec_0190776 VERIFIED: YES
Provenance & Taxonomy
Rana rugosa [Animal]
Gaegurin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Antiparasitic Antiprotozoal Anti-Gram-positive Anti-Gram-negative
Eshchericia coli
25 μg/mL
MIC
PMID7999137 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7999137/
RECORD: Rec_0210605 VERIFIED: YES
Provenance & Taxonomy
Glandirana rugosa [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
27-33
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Micrococcus luteus
5 μg/mL
MIC
PaperAntimicrobial peptides from the skin of a Korean frog, Rana rugosa. Biochem Biophys Res Commun. 1994 Nov 30;205(1):948-954. doi: 10.1006/bbrc.1994.2757. PMID: 7999137. PMID7999137 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7999137/
RECORD: Rec_0214751 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 57.6%, E 0.0%, T 24.2%, C 18.2% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial Antiparasitic Toxic Antimicrobial Antifungal Hemolytic
PaperHemolytik: a database of experimentally determined hemolytic and non-hemolytic peptides PMID24174543 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24174543/
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