Peptide Database

Peptide NameSLAY-screened peptide P1197

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC108H158N28O33S

DescriptionStandard

        RKDIVCYYVSSHTYNALDNF
    

Molecular Weight2408.64 Da

Isoelectric Point (pI)6.74

Net Charge (pH 7.0)-0.16

Net Charge (pH 7.4) -0.44

Charge Density (pH 7.0) -0.0082

GRAVY Index-0.40

Hydrophobic Moment 0.38

Boman Index-0.04

Instability Index9.77

Aliphatic Index 73.00

Aromaticity 0.2000

Extinction Coeff. Reduced 4470.00

Extinction Coeff. Oxidized 4470.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1014.98

LogP -9.53

H-bond Donors 37.0

H-bond Acceptors 35.0

Rotatable Bonds 75.0

Heavy Atoms 170.0

Ring Count 5.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0293782 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/