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MYP_095725
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Basic Information
CRAMP-18 E2K
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
18 amino acids
C102H176N28O22
Standard
Sequence
GKKLKKIGQKIKNFFQKL
Physicochemical Analysis
2146.66 Da
10.78
6.75
6.54
0.3752
-0.91
0.76
-0.26
-31.92
86.67
0.1111
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
869.43
-5.12
29.0
29.0
83.0
152.0
2.0
20.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0291077 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
tumor cells: A549
25 μM
IC50
PaperCRAMP analogues having potent antibiotic activity against bacterial, fungal, and tumor cells without hemolytic activity.
RECORD: Rec_0315941 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
Staphylococcus aureus KCTC 1621
1.56 μM
MIC
PaperCRAMP analogues having potent antibiotic activity against bacterial, fungal, and tumor cells without hemolytic activity.
RECORD: Rec_0316520 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
Salmonella Typhimurium KCTC 1926
1.56 μM
MIC
PaperCRAMP analogues having potent antibiotic activity against bacterial, fungal, and tumor cells without hemolytic activity.
RECORD: Rec_0337716 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
Human erythrocytes
100 μM
Hemolysis
Paperhttps://pubmed.ncbi.nlm.nih.gov/10973820/ PMID10973820 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10973820/
RECORD: Rec_0342804 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
S. pyogenes KCTC 3096
3.12 μM
MIC
PaperCRAMP analogues having potent antibiotic activity against bacterial, fungal, and tumor cells without hemolytic activity.
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