Peptide Database

Peptide NameEC-hepcidin2

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antiviral

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition

Standard StatusStandard

Sequence Length87 amino acids

Chemical FormulaC418H665N115O127S6

DescriptionStandard

        MKTFSVAVAVAVVLAFICTQESSALPVTGIEELVEPVSSDNNDNHQGLPVELRERLVNIRKKRAPTDCIPYCYPTGDGFHCGVTCRF
    

Molecular Weight9525.84 Da

Isoelectric Point (pI)5.55

Net Charge (pH 7.0)-2.36

Net Charge (pH 7.4) -2.77

Charge Density (pH 7.0) -0.0271

GRAVY Index0.05

Hydrophobic Moment 0.52

Boman Index0.07

Instability Index54.55

Aliphatic Index 88.39

Aromaticity 0.0690

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 3230.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3852.63

LogP -39.65

H-bond Donors 136.0

H-bond Acceptors 133.0

Rotatable Bonds 305.0

Heavy Atoms 666.0

Ring Count 14.0

Amide Bonds 92.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0307459 VERIFIED: NO

Provenance & Taxonomy

OrganismActinopterygii [Animal]

FamilyHepcidin

Tax ID7898

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial

RECORD: Rec_0347625 VERIFIED: YES

Provenance & Taxonomy

OrganismEpinephelus coioides [Animal]

Tax ID94232

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Other ModsThere are two pairs of disulfide bonds.

Bio-Activity Profile

Function

Antiviral Anti-SGIV Entry inhibition

TargetSingapore grouper iridovirus (SGIV)

Half-LifeMammalian: 30 h; Yeast: >20 h; E. coli: >10 h

PaperMolecular cloning and characterization of two novel hepcidins from orange-spotted grouper, Epinephelus coioides. | Zhou JG, Wei JG, Xu D, Cui HC, Yan Y, Ou-Yang ZL, Huang XH, Huang YH, Qin QW. | Fish Shellfish Immunol. 2011 Feb;30(2):559-68. | DOI:10.1016/j.fsi.2010.11.021 | PMID:21145974 PMID21145974 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21145974/

RECORD: Rec_0425047 VERIFIED: YES

Provenance & Taxonomy

OrganismEpinephelus coioides [Animal]

FamilyHepcidin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative

TargetStaphylococcus aureus

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