Peptide Database

Peptide NameEndothelin-1

Function Ontology

Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide

Cardiovascular ▸ Vascular tone modulation ▸ Vasoconstrictor activity

Hormonal / Endocrine ▸ Hormone peptide

Regulatory peptide ▸ Biological modulation

Standard StatusStandard

Sequence Length76 amino acids

Chemical FormulaC368H609N117O108S7

DescriptionStandard

        VVPYGLGSPRSKRALENLLPTKATDRENRCQCASQKDKKCWNFCQAGKELRAKDLMEKGWNNHKKGKDCSKLGKKC
    

Molecular Weight8624.95 Da

Isoelectric Point (pI)9.70

Net Charge (pH 7.0)10.76

Net Charge (pH 7.4) 10.38

Charge Density (pH 7.0) 0.1416

GRAVY Index-1.15

Hydrophobic Moment 0.61

Boman Index-0.35

Instability Index31.09

Aliphatic Index 50.13

Aromaticity 0.0526

Extinction Coeff. Reduced 12490.00

Extinction Coeff. Oxidized 12865.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3738.22

LogP -42.88

H-bond Donors 135.0

H-bond Acceptors 127.0

Rotatable Bonds 304.0

Heavy Atoms 600.0

Ring Count 10.0

Amide Bonds 83.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0064474 VERIFIED: YES

Provenance & Taxonomy

OrganismMacaca fascicularis [Animal]

FamilyEndothelin

Tax ID9541

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Hormone Endocrine Vasoactive Vasoconstrictor Receptor modulation

Targetcoupled receptors

Half-LifeMammalian: 100 hour; Yeast: >20 hour; E. coli: >10 hour

RECORD: Rec_0281889 VERIFIED: YES