Peptide Database

Peptide NameUnnamed

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antiviral

Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition

Enzyme modulation ▸ Enzyme inhibition ▸ Binding inhibition

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Toxin-related activity

Standard StatusStandard

Sequence Length15 amino acids

Chemical FormulaC84H133N23O24

DescriptionStandard

        HEVVPLEVYTRHEIK
    

Molecular Weight1849.09 Da

Isoelectric Point (pI)6.02

Net Charge (pH 7.0)-1.06

Net Charge (pH 7.4) -1.37

Charge Density (pH 7.0) -0.0706

GRAVY Index-0.53

Hydrophobic Moment 0.33

Boman Index-0.07

Instability Index31.51

Aliphatic Index 110.00

Aromaticity 0.0667

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 759.57

LogP -4.00

H-bond Donors 26.0

H-bond Acceptors 25.0

Rotatable Bonds 59.0

Heavy Atoms 131.0

Ring Count 4.0

Amide Bonds 14.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0353373 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyProtein-derived synthetic peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Binding inhibition

Targetinhibition of virus attachment on Vero cells

Activity200 μM

MethodEC50

Half-LifeMammalian: 3.5 h; Yeast: 10 min; E. coli: >10 h

PaperMultiple peptides homologous to herpes simplex virus type 1 glycoprotein B inhibit viral infection. | Akkarawongsa R, Pocaro NE, Case G, Kolb AW, Brandt CR. | Antimicrob Agents Chemother. 2009 Mar;53(3):987-96. | DOI:10.1128/AAC.00793-08 | PMID:19104014 PMID19104014 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19104014/

RECORD: Rec_0425877 VERIFIED: YES